Description

2'-Deoxythymidine-5'-(α-Methylphosphonyl)-Beta,γ-Diphosphate is a chemically modified nucleotide analog, specifically a thymidine diphosphate derivative with an α-methylphosphonyl group. This structural modification is critical for its role as a potent and selective inhibitor of viral DNA polymerases and reverse transcriptases. It is an essential research-grade biochemical for pharmaceutical R&D, particularly in the development of novel antiviral and anticancer nucleoside analogs. The compound is supplied as a high-purity solid for use in biochemical assays, enzymatic studies, and as a key intermediate in medicinal chemistry.

Application

• Antiviral Drug Research: Serves as a key biochemical tool and potential intermediate in the development of nucleoside reverse transcriptase inhibitors (NRTIs) for HIV and other viral targets.
• Enzymology Studies: Used as a substrate analog to investigate the mechanism, kinetics, and inhibition of viral DNA polymerases and cellular polymerases.
• Medicinal Chemistry Synthesis: Acts as a sophisticated building block for the synthesis of novel nucleotide prodrugs and modified nucleosides with enhanced therapeutic profiles.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) assays to identify and characterize new antiviral compounds.
• Oncology Research: Investigated for its potential to inhibit DNA replication in rapidly dividing cancer cells, supporting anticancer drug discovery programs.
• Molecular Biology: Used in specialized studies of DNA metabolism, repair, and the function of nucleotide-binding proteins.

Basic Information

Product Name	2'-Deoxythymidine-5'-(α-Methylphosphonyl)-Beta,γ-Diphosphate
CAS No.	138989-23-8
Molecular Formula	C11H19N2O13P3
Molecular Weight	504.19 g/mol
Synonyms	dTMP-α-methylphosphonyl-β,γ-diphosphate; Thymidine 5'-(α-methylphosphonyl)-β,γ-diphosphate; α-Methylphosphonyl-dTDP; 2'-Deoxy-5'-O-{[(α-methylphosphonyl)-β,γ-diphosphono]oxy}thymidine; dTMP-α-CH3-pp; Nucleotide analog inhibitor; Modified thymidine diphosphate; Antiviral nucleotide intermediate
EINECS	Contact for details

Quality Control

Our 2'-Deoxythymidine-5'-(α-Methylphosphonyl)-Beta,γ-Diphosphate is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.