Description

n-(5,5-Diacetoxypentyl)Doxorubicin is a chemically modified derivative of the potent anthracycline antibiotic, doxorubicin. This compound is engineered to serve as a key intermediate or prodrug in advanced pharmaceutical research, particularly in the development of targeted cancer therapeutics. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery and the synthesis of novel chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel doxorubicin prodrugs and conjugates designed for targeted drug delivery.
• Oncology Research: Used in preclinical studies to investigate new mechanisms of action, improve therapeutic efficacy, and reduce systemic toxicity of anthracycline-based treatments.
• Prodrug Development: Acts as a model compound for designing prodrugs that are activated specifically within tumor microenvironments.
• Bioconjugation Studies: Employed in research focusing on linking chemotherapeutic agents to antibodies, peptides, or polymers for enhanced targeting.
• Chemical Biology: Utilized as a tool compound to study cellular uptake, drug resistance mechanisms, and apoptosis pathways.
• Analytical Reference Standard: Functions as a high-purity standard for method development and quality control in analytical laboratories.

Basic Information

Product Name	n-(5,5-Diacetoxypentyl)Doxorubicin
CAS No.	138967-27-8
Molecular Formula	C₃₅H₄₁NO₁₆
Molecular Weight	731.70 g/mol
Synonyms	5,5-Diacetoxypentyl Doxorubicin; Doxorubicin-14-O-(5,5-diacetoxypentyl)ether; AD 198 derivative; NSC-D739932; 14-O-(5,5-Diacetoxypentyl)doxorubicin; Doxorubicin pentyl diacetate derivative; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione 14-(5,5-diacetoxypentyl) ether
EINECS	Contact for details

Quality Control

Our n-(5,5-Diacetoxypentyl)Doxorubicin is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing specifications such as HPLC purity, related substances, and residual solvents. We adhere to stringent quality management protocols suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the container to reach room temperature in a desiccator before opening to prevent condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Maximum Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.