Description

2'-Deoxy-2'-Fluoroguanylyl-3',5'-Cytidine is a chemically modified dinucleotide, specifically a fluorinated guanylyl-cytidine derivative. This compound is of significant value as a critical building block and research tool in the development of oligonucleotide therapeutics, including antisense and siRNA applications. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic research institutions focused on advanced nucleic acid chemistry and drug discovery.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of therapeutic oligonucleotides.
• Antisense Drug Development: Used to incorporate 2'-fluoro modifications, enhancing nuclease resistance and binding affinity of antisense oligonucleotides.
• siRNA and RNAi Research: Essential for constructing chemically stabilized siRNA duplexes to improve pharmacokinetic properties and efficacy.
• Structural Biology Studies: Employed in NMR and X-ray crystallography to study RNA structure, dynamics, and protein-RNA interactions.
• Diagnostic Probe Development: Used in the creation of high-affinity, nuclease-resistant hybridization probes for molecular diagnostics.
• Medicinal Chemistry Research: Serves as a vital intermediate for exploring structure-activity relationships (SAR) in nucleic acid-based drug candidates.

Basic Information

Product Name	2'-Deoxy-2'-Fluoroguanylyl-3',5'-Cytidine
CAS No.	138853-61-9
Molecular Formula	C19H24FN9O11P
Molecular Weight	595.42 g/mol
Synonyms	2'-F-GpC; 2'-Deoxy-2'-fluoroguanylyl-(3'→5')-cytidine; 2'-Fluoro-GpC; Guanylyl(3'-5')cytidine, 2'-deoxy-2'-fluoro-; 2'-F-dGpC; Fluorinated GpC dinucleotide; 2'-Fluoro-2'-deoxyguanylyl-cytidine; pGpC, 2'-deoxy-2'-fluoro-
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-2'-Fluoroguanylyl-3',5'-Cytidine is manufactured under strict quality systems suitable for research and pharmaceutical development. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 90%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.