Description

Zankiren CAS NO 138742-43-5 is a potent and selective renin inhibitor, representing a significant class of compounds for cardiovascular research. This high-purity intermediate is critical for the development of novel antihypertensive agents and for studying the renin-angiotensin-aldosterone system (RAAS). It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and academic institutions engaged in metabolic and cardiovascular disease research.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced renin inhibitor drug candidates.
• Biochemical Research: Used as a reference standard and tool compound for studying renin enzyme kinetics and inhibition mechanisms.
• Preclinical Development: Employed in the formulation and efficacy testing of new antihypertensive therapies in animal models.
• Metabolic Pathway Analysis: Facilitates research into the RAAS pathway and its role in blood pressure regulation and kidney function.
• High-Throughput Screening (HTS): Serves as a positive control or pharmacophore model in screening assays for new renin-targeting molecules.

Basic Information

Item	Detail
Product Name	Zankiren
CAS No.	138742-43-5
Molecular Formula	C30H41N5O5
Molecular Weight	551.68 g/mol
Synonyms	Zankiren Hydrochloride; (2S,4S,5S)-5-Amino-6-cyclohexyl-N-[(2S,4S)-1-[(3S,5S)-5-(aminomethyl)-3-methyl-2-oxo-1-pyrrolidinyl]-4-methyl-1-oxo-2-pentanyl]-2-(2-methylpropyl)-4-[[(2S)-2-[[(4-morpholinylcarbonyl)amino]methyl]-1-oxohexyl]amino]-1,6-diphenyl-3-hexeneamide; A-72517; A 72517; Renin Inhibitor A-72517
EINECS	Contact for details

Quality Control

Our Zankiren is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.