Description

2''-o-Carbamylnovobiocin is a chemically modified derivative of the natural antibiotic novobiocin, designed for advanced research and development applications. This compound is valued for its role as a key intermediate in the synthesis of novel antibacterial agents and as a critical tool for studying bacterial DNA gyrase inhibition. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers focused on developing next-generation therapeutics. Our supply ensures high purity and batch-to-batch consistency to support critical discovery and process development work.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel antibiotic candidates and semi-synthetic derivatives.
• Biochemical Research: Used as a reference standard and probe compound in studies targeting bacterial DNA gyrase and topoisomerase IV enzymes.
• Antimicrobial Mechanism Studies: Employed in microbiological research to investigate structure-activity relationships (SAR) and resistance mechanisms.
• Process Chemistry: Acts as a starting material or intermediate in scale-up and optimization for API (Active Pharmaceutical Ingredient) manufacturing.
• Analytical Standard: Provides a high-purity standard for HPLC, LC-MS, and NMR method development and validation in quality control laboratories.

Basic Information

Product Name	2''-o-Carbamylnovobiocin
CAS No.	138686-58-5
Molecular Formula	C₃₂H₃₆N₄O₁₁
Molecular Weight	652.65 g/mol
Synonyms	Novobiocin carbamate; 2''-O-Carbamoylnovobiocin; 2'-O-Carbamylnovobiocin; Novobiocin, 2''-O-carbamoyl-; 5'''-Demethyl-2''-O-carbamoylnovobiocin; Antibiotic U-65913; (2S)-N-{3-[(2R,3S,4R,5S)-5-[(2S,3R,4S,5R,6R)-4-[(2R,3R,4R,5R,6S)-4,5-Dihydroxy-6-methyl-3-(methylamino)oxan-2-yl]oxy-3,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-2-(4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamido)-3-methyl-6-oxohexahydro-2H-pyran-2-yl]-2-hydroxybenzoyl}-2,4-dimethoxybenzenesulfonamide
EINECS	Contact for details

Quality Control

Our 2''-o-Carbamylnovobiocin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay	95.0 - 102.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.