Description

1H-Imidazole-4-Carbonyl Chloride, 2,5-Dihydro-2-Oxo- (9Ci) is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in constructing complex molecular architectures, particularly those containing the imidazole pharmacophore. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those targeting enzymes and receptors where the imidazole moiety is essential for biological activity.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, where its reactive carbonyl chloride group enables the introduction of complex side chains.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in coordination chemistry and catalysis, especially in asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic materials, such as polymers or metal-organic frameworks (MOFs) with specific functional properties.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Item	Details
Product Name	1H-Imidazole-4-Carbonyl Chloride, 2,5-Dihydro-2-Oxo- (9Ci)
CAS No.	138113-11-8
Molecular Formula	C4H3ClN2O2
Molecular Weight	146.53 g/mol
Synonyms	2-Oxo-2,5-dihydro-1H-imidazole-4-carbonyl chloride; 4-(Chlorocarbonyl)-2,5-dihydro-2-oxoimidazole; 1H-Imidazole-4-carbonyl chloride, 2,5-dihydro-2-oxo-; 2,5-Dihydro-2-oxo-1H-imidazole-4-carbonyl chloride; 4-Imidazolecarbonyl chloride, 2,5-dihydro-2-oxo-; 2-Oxo-2,3-dihydroimidazole-4-carbonyl chloride (tautomeric form); 138113-11-8 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 1H-Imidazole-4-Carbonyl Chloride, 2,5-Dihydro-2-Oxo- (9Ci) is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (by HPLC), impurity profile, and physical characteristics are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended long-term storage temperature is 2-8°C (refrigerated).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.