Description

tert-Butyl n-(2-Isothiocyanatoethyl)Carbamate is a specialized bifunctional organic compound that serves as a critical building block in advanced organic synthesis. Its value lies in the combination of a protected amine group and a highly reactive isothiocyanate moiety, enabling precise molecular construction. This reagent is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry for creating urea/thiourea derivatives.
• Peptide Mimetics & Bioconjugation: Used to introduce thiourea linkages or for site-specific labeling of biomolecules, enabling the creation of peptide mimetics and antibody-drug conjugates (ADCs).
• Agrochemical Synthesis: Intermediate in the production of advanced pesticides and herbicides that require specific thiourea or guanidine functional groups.
• Chemical Biology Probes: Employed in the development of activity-based probes (ABPs) and other research tools for studying enzyme function and protein interactions.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for synthesizing functional polymers with tailored properties.
• Material Science Research: Used in surface modification and the creation of novel organic-inorganic hybrid materials.

Basic Information

Product Name	tert-Butyl n-(2-Isothiocyanatoethyl)Carbamate
CAS No.	137743-46-5
Molecular Formula	C8H14N2O2S
Molecular Weight	202.27 g/mol
Synonyms	Boc-NH-CH2-CH2-NCS; 2-[(tert-Butoxycarbonyl)amino]ethyl isothiocyanate; N-Boc-2-aminoethyl isothiocyanate; N-(tert-Butoxycarbonyl)-2-aminoethyl isothiocyanate; 2-Isothiocyanatoethyl carbamic acid tert-butyl ester; tert-Butyl (2-isothiocyanatoethyl)carbamate; 2-(Boc-amino)ethyl isothiocyanate; N-(2-Isothiocyanatoethyl)-N-Boc-amine
EINECS	Contact for details

Quality Control

Our tert-Butyl n-(2-Isothiocyanatoethyl)Carbamate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and cGMP manufacturing. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.