Description

3-Chloro-4-Fluorophenyl Isothiocyanate is a versatile and highly reactive aromatic isothiocyanate derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its ability to introduce the thiourea pharmacophore, a key structural motif for modulating biological activity and material properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of thiourea-based drug candidates, particularly for kinase inhibitors, antimicrobials, and anticancer agents.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and pesticides with enhanced efficacy and selectivity.
• Chemical Biology & Proteomics: Used as an active-site directed probe or labeling reagent for studying enzyme function and protein interactions.
• Material Science: Monomer or cross-linking agent in the production of specialty polymers, resins, and coatings with tailored thermal or mechanical properties.
• Dye & Pigment Manufacturing: Intermediate in the synthesis of specialized heterocyclic dyes and colorants.

Basic Information

Item	Details
Product Name	3-Chloro-4-Fluorophenyl Isothiocyanate
CAS No.	137724-66-4
Molecular Formula	C7H3ClFNS
Molecular Weight	187.62 g/mol
Synonyms	1-Chloro-2-fluoro-4-isothiocyanatobenzene; 4-Fluoro-3-chlorophenyl isothiocyanate; 3-Chloro-4-fluorophenyl mustard oil; (3-Chloro-4-fluorophenyl)carbonimidothioic acid; Isothiocyanic acid, 3-chloro-4-fluorophenyl ester; NSC 405124; 3-Cl-4-F-Ph-NCS
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluorophenyl Isothiocyanate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as bases, amines, and alcohols. The container should be kept tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.