Description

2',3'-Dideoxyinosine Triphosphate Trisodium Salt is a chemically modified nucleotide triphosphate analog, specifically engineered for research applications requiring chain termination. This compound is critical for biochemical studies involving DNA synthesis and sequencing, where it acts as a substrate for various polymerases. It is primarily utilized by researchers and manufacturers in the fields of molecular biology, enzymology, and pharmaceutical development for investigating nucleic acid metabolism and designing novel therapeutic agents.

Application

• Molecular Biology Research: Used as a substrate analog in enzymatic studies of DNA polymerases and reverse transcriptases to investigate mechanisms of chain termination.
• Biochemical Assay Development: Serves as a key reagent in the development of in vitro assays for screening potential antiviral or anticancer compounds that target nucleotide metabolism.
• Nucleic Acid Sequencing: Employed in specialized sequencing methodologies that utilize dideoxy nucleotide analogs to study DNA structure and function.
• Enzymology Studies: Acts as a tool compound to study enzyme kinetics, substrate specificity, and inhibition profiles of nucleoside/nucleotide-processing enzymes.
• Pharmaceutical R&D: Used in early-stage research for the development of nucleotide-based prodrugs and therapeutic agents targeting viral replication.
• Diagnostic Kit Manufacturing: Incorporated as a specialized component in kits for research and diagnostic applications related to genetic analysis.

Basic Information

Product Name	2',3'-Dideoxyinosine Triphosphate Trisodium Salt
CAS No.	137629-34-6
Molecular Formula	C10H12N4O12P3Na3 • xH2O
Molecular Weight	Anhydrous: 590.08 g/mol (Contact for exact hydrated form)
Synonyms	ddITP Trisodium Salt; 2',3'-Dideoxyinosine 5'-triphosphate trisodium salt; 2',3'-ddITP Na3; ddInosine triphosphate trisodium; Inosine, 2',3'-dideoxy-, 5'-(trihydrogen triphosphate), trisodium salt; 9-[(2R,3S,5R)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,9-dihydro-3H-purin-6-one 5'-(triphosphate) trisodium salt (related IUPAC form); Dideoxyinosine triphosphate sodium salt
EINECS	Contact for details

Quality Control

Our 2',3'-Dideoxyinosine Triphosphate Trisodium Salt is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) with detailed chromatographic data and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (Karl Fischer)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Endotoxin (LAL)	< 10 EU/mg (for applicable grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.