Description

5-Bromo-1-(2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl)Cytosine is a high-purity nucleoside analogue derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a key scaffold for the development of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of modified nucleosides. The compound, identified by CAS number 137530-43-9, is valued for its precise chemical structure which enables targeted modifications in drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiviral and anticancer nucleoside analogues.
• Antiviral Research: Used as a precursor in the development of potential therapeutic agents targeting viral polymerases.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug efficacy and reduce toxicity.
• Biochemical Research: Employed in studies investigating nucleotide metabolism and enzyme inhibition mechanisms.
• Fine Chemical Synthesis: Utilized in custom synthesis and contract manufacturing for specialized, high-value chemical entities.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	5-Bromo-1-(2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl)Cytosine
CAS No.	137530-43-9
Molecular Formula	C9H12BrN3O4S
Molecular Weight	338.18 g/mol
Synonyms	5-Bromo-L-OddC; 5-Bromo-β-L-1,3-Oxathiolanylcytosine; 5-Bromo-1-[(2S,5R)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine; 5-Br-L-OddC; 5-Bromo-2'-deoxy-3'-thiacytidine analogue; B-L-OddC; 137530-43-9; 5-Bromo-3TC intermediate
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-(2-(Hydroxymethyl)-1,3-Oxathiolan-5-Yl)Cytosine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.