Description

N,n-Dimethyl-1-(Trimethylsilyl)Methanesulfonamide is a specialized organosilicon reagent featuring a protected sulfonamide group. This compound is valued for its role as a versatile building block and protecting group in advanced organic synthesis, particularly for sensitive nitrogen-containing molecules. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors to facilitate complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing sulfonamide or sulfonylurea moieties.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where the trimethylsilyl-protected sulfonamide group is required.
• Peptide & Nucleoside Chemistry: Serves as a protecting group for amines during multi-step synthesis, preventing unwanted side reactions.
• Material Science Research: Employed in the development of specialty polymers and functional materials that incorporate silicon and sulfur-based functional groups.
• Cross-Coupling Reactions: Acts as a substrate or reagent in palladium-catalyzed and other metal-mediated coupling reactions to construct complex molecular architectures.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of high-value fine chemicals.

Basic Information

Product Name	N,n-Dimethyl-1-(Trimethylsilyl)Methanesulfonamide
CAS No.	137474-32-9
Molecular Formula	C7H19NO2SSi
Molecular Weight	193.38 g/mol
Synonyms	N,N-Dimethyl-1-(trimethylsilyl)methanesulfonamide; N,N-Dimethyl-1-(trimethylsilyl)methanesulphonamide; Methanesulfonamide, N,N-dimethyl-1-(trimethylsilyl)-; (Trimethylsilyl)methanesulfonamide, N,N-dimethyl-; TMS-Protected Dimethylsulfonamide; N,N-Dimethyl(trimethylsilylmethyl)sulfonamide; N,N-Dimethyl-α-(trimethylsilyl)methanesulfonamide
EINECS	Contact for details

Quality Control

Our N,n-Dimethyl-1-(Trimethylsilyl)Methanesulfonamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.