Description

Rel-(R,R)-Voriconazole is a high-purity stereoisomer of the broad-spectrum triazole antifungal agent, Voriconazole. This specific enantiomer is of critical importance for pharmaceutical research and development, particularly in the study of structure-activity relationships and metabolic pathways. It serves as a key chiral intermediate and reference standard for analytical method development and quality control in the production of advanced antifungal medications. Researchers and manufacturers in the global pharmaceutical and fine chemical sectors require this material for developing more effective and targeted therapeutic solutions.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of enantiomerically pure Voriconazole and related triazole antifungal drugs.
• Analytical Reference Standard: Used as a high-purity standard for HPLC, LC-MS, and other chromatographic methods to quantify and qualify Voriconazole in active pharmaceutical ingredients (APIs) and finished drug products.
• Metabolism and Pharmacokinetics Studies: Essential for investigating the stereoselective metabolism, bioavailability, and efficacy of Voriconazole enantiomers in preclinical and clinical research.
• Process Development & Optimization: Employed in R&D to develop and validate asymmetric synthesis routes and purification processes for antifungal agents.
• Impurity Profiling: Used to identify, characterize, and control stereoisomeric impurities during the manufacturing of Voriconazole API to ensure compliance with ICH guidelines.
• Academic and Institutional Research: A valuable tool for universities and research institutes studying antifungal mechanisms of action, resistance, and novel drug design.

Basic Information

Product Name	Rel-(R,R)-Voriconazole
CAS No.	137330-52-0
Molecular Formula	C16H14F3N5O
Molecular Weight	349.31 g/mol
Synonyms	(2R,3S)-Voriconazole; (R,R)-Voriconazole; Voriconazole Enantiomer; (αR,βS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; UK-109496 Enantiomer; Antifungal Agent UK-109496 Isomer
EINECS	Contact for details

Quality Control

Our Rel-(R,R)-Voriconazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, identification, and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment. We support compliance with relevant pharmacopeial and ICH guidelines for impurities and stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.