Description

Voriconazole (2R,3R)-Isomer is the specific, pharmacologically active stereoisomer of the broad-spectrum triazole antifungal agent, Voriconazole. This high-purity enantiomer is critical for pharmaceutical development and manufacturing, ensuring optimal efficacy and safety profiles in final drug formulations. It is an essential advanced pharmaceutical intermediate for producers of antifungal medications targeting severe systemic fungal infections.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Primary use as the key chiral building block in the manufacture of Voriconazole API.
• Pharmaceutical R&D: Critical for preclinical and clinical studies to establish pharmacokinetic and pharmacodynamic data for the pure enantiomer.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for analytical method development and quality control testing.
• Process Chemistry: Used in route scouting and optimization for more efficient and stereoselective synthesis processes.
• Generic Drug Manufacturing: Essential for companies developing bioequivalent generic versions of branded Voriconazole products.

Basic Information

Product Name	Voriconazole (2R,3R)-Isomer
CAS No.	137234-76-5
Molecular Formula	C16H14F3N5O
Molecular Weight	349.31 g/mol
Synonyms	(2R,3R)-Voriconazole; (2R,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; UK-109496 (2R,3R)-Isomer; (αR,βR)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol; Voriconazole Enantiomer; (R,R)-Voriconazole
EINECS	Contact for details

Quality Control

Our Voriconazole (2R,3R)-Isomer is manufactured under strict quality management systems. Each batch is tested to meet exacting standards for chiral purity, chemical purity, and identity, suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided with each shipment, detailing comprehensive analytical results from validated methods, including chiral HPLC for enantiomeric excess determination.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.