Description

5-Formyl-2'-Deoxycytidine is a modified nucleoside analog of deoxycytidine, featuring a formyl group at the 5-position of the cytosine base. This structural modification makes it a critical intermediate and research tool in the study of DNA damage, repair mechanisms, and epigenetic modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced nucleic acid chemistry, oncology research, and the development of novel therapeutic agents. The compound's high purity and stability are essential for reproducible experimental results in sensitive biochemical assays.

Application

• Biochemical Research: A key substrate for studying oxidative DNA damage and the formation of formylpyrimidine lesions.
• Epigenetics & Cancer Research: Investigated for its role as a potential epigenetic marker and in pathways related to carcinogenesis.
• Nucleoside Chemistry: Serves as a versatile synthetic intermediate for the preparation of more complex nucleoside derivatives and prodrugs.
• Antiviral/Anticancer Agent Development: Used in the research and development of novel nucleoside-based therapeutics targeting viral replication or cancer cell proliferation.
• Diagnostic Reagent Synthesis: Employed in the creation of probes and reagents for detecting specific DNA modifications or repair enzyme activity.
• Enzyme Substrate Studies: Acts as a specific substrate for DNA repair enzymes like thymine DNA glycosylase (TDG) and other base excision repair (BER) pathway proteins.

Basic Information

Product Name	5-Formyl-2'-Deoxycytidine
CAS No.	137017-45-9
Molecular Formula	C10H13N3O5
Molecular Weight	255.23 g/mol
Synonyms	5-Formyldeoxycytidine; 5-foC; 5-Formyl-dC; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-formyl-2-oxo-1,2-dihydropyrimidine-4-amine; 5-Formyl-2'-deoxycytidine; 5-Formylcytosine deoxyribonucleoside; 5fC
EINECS	Contact for details

Quality Control

Our 5-Formyl-2'-Deoxycytidine is manufactured under controlled conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.