Description

2-Pyrrolidinecarbonyl Chloride, 1-(Aminocarbonyl)-, (S)- (9Ci) is a chiral, activated carboxylic acid derivative of L-proline, serving as a critical building block for the synthesis of complex molecules. Its value lies in enabling the efficient, stereoselective introduction of the (S)-pyrrolidine-2-carboxamide moiety, a privileged scaffold found in numerous bioactive compounds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, particularly protease inhibitors and other enzyme-targeted therapies.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of active pharmaceutical ingredients (APIs), especially protease inhibitors (e.g., for HIV, HCV) and kinase inhibitors.
• Peptidomimetic Chemistry: Used to incorporate modified proline units into peptide backbones to enhance metabolic stability, bioavailability, and receptor selectivity.
• Agrochemical Synthesis: Building block for creating novel chiral herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profile.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and affinity labels for studying enzyme function and mechanism.
• Asymmetric Catalysis Ligand Synthesis: Precursor for chiral ligands and organocatalysts used in enantioselective transformations.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	2-Pyrrolidinecarbonyl Chloride, 1-(Aminocarbonyl)-, (S)- (9Ci)
CAS No.	137004-50-3
Molecular Formula	C6H9ClN2O2
Molecular Weight	176.60 g/mol
Synonyms	(S)-1-Carbamoylpyrrolidine-2-carbonyl chloride; L-Proline, 1-carbamoyl-, chloride (9CI); 1-Carbamoyl-L-proline chloride; N-Carbamoyl-L-proline chloride; (S)-N-Carbamoylpyrrolidine-2-carbonyl chloride; 1-Aminocarbonyl-L-proline chloride; (2S)-1-(Aminocarbonyl)-2-pyrrolidinecarbonyl chloride; Pyrrolidine-2-carbonyl chloride, 1-(aminocarbonyl)-, (S)-
EINECS	Contact for details

Quality Control

Our 2-Pyrrolidinecarbonyl Chloride, 1-(Aminocarbonyl)-, (S)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent hydrolysis. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.