Description

2'-Thioadenosine is a chemically modified nucleoside analog where the 2'-hydroxyl group of the ribose sugar is replaced by a thiol group. This structural modification is of significant interest in biochemical research and pharmaceutical development, particularly for studying RNA function and as a potential building block for novel therapeutics. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, antiviral drug discovery, and molecular biology. The compound's unique properties make it a valuable tool for probing enzyme mechanisms and designing targeted inhibitors.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for RNA-modifying enzymes and nucleoside kinases.
• Antiviral Drug Development: Serves as a key intermediate or analog in the synthesis of potential nucleoside-based antiviral agents.
• RNA Structure & Function Studies: Incorporated into oligonucleotides to investigate RNA stability, folding, and protein-RNA interactions.
• Medicinal Chemistry: Acts as a building block for creating novel nucleoside derivatives with tailored biological activities.
• Enzyme Mechanism Probes: Utilized to study the catalytic mechanisms of ribonucleases and other nucleoside-processing enzymes.
• Diagnostic Reagent Synthesis: May be used in the preparation of labeled probes or other diagnostic compounds.

Basic Information

Product Name	2'-Thioadenosine
CAS No.	136904-69-3
Molecular Formula	C10H13N5O3S
Molecular Weight	283.31 g/mol
Synonyms	2'-Thioadenosine; 2'-Deoxy-2'-thioadenosine; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-thiolanyl]adenine; 2'-S-Adenosine; Adenosine, 2'-thio-; 2'-Thio-Ado
EINECS	Contact for details

Quality Control

Our 2'-Thioadenosine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure identity, potency, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all specified parameters. Our quality systems are designed to support research and development requiring high-purity biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.