Description

12Beta-Hydroxy-3-Oxo-5Beta-Cholanoic Acid is a high-purity bile acid derivative and a key intermediate in the synthesis of pharmaceutical compounds. This compound matters for its role in developing therapeutic agents targeting liver and metabolic functions, where precise stereochemistry is critical for biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel drugs, diagnostic agents, and biochemical research.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of ursodeoxycholic acid (UDCA) analogs and other therapeutic bile acids.
• Biochemical Research: Used as a reference standard and precursor in studies of bile acid metabolism, liver function, and cholestatic diseases.
• Diagnostic Agent Development: Serves as a starting material for creating labeled compounds used in clinical diagnostics and imaging.
• Metabolic Pathway Studies: Employed in academic and industrial research to investigate enzymatic pathways and receptor interactions.
• Active Pharmaceutical Ingredient (API) Synthesis: A key chiral intermediate in multi-step synthetic routes for high-value APIs.

Basic Information

Product Name	12Beta-Hydroxy-3-Oxo-5Beta-Cholanoic Acid
CAS No.	136892-43-8
Molecular Formula	C₂₄H₃₈O₅
Molecular Weight	406.56 g/mol
Synonyms	3-Oxo-12β-hydroxy-5β-cholan-24-oic Acid; 12β-Hydroxy-3-oxo-5β-cholanic Acid; 12β-Hydroxy-3-oxolithocholic Acid; 12β-Hydroxy-3-oxo-5β-cholanoate; 5β-Cholan-24-oic acid, 12β-hydroxy-3-oxo-; 12β-Hydroxy-3-keto-5β-cholanoic Acid
EINECS	Contact for details

Quality Control

Our 12Beta-Hydroxy-3-Oxo-5Beta-Cholanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Specific Rotation	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.