Description

8-Hydroxy-N2-Isobutryl-2'-Deoxyguanosine is a chemically modified nucleoside derivative of deoxyguanosine, featuring an isobutyryl group at the N2 position and a hydroxyl group at the 8-position. This specific modification makes it a valuable biochemical tool and a critical reference standard for research into oxidative DNA damage and repair mechanisms. It is primarily sought after by research institutions, diagnostic manufacturers, and pharmaceutical companies engaged in advanced studies of mutagenesis, carcinogenesis, and biomarker discovery.

Application

• Biomarker Research: Serves as a critical reference standard for the detection and quantification of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a key biomarker of oxidative stress and DNA damage in biological samples.
• Analytical Chemistry: Used as a high-purity calibrant and internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and HPLC-ECD methods for accurate bioanalytical measurements.
• Pharmaceutical R&D: Employed in studies investigating the mechanisms of DNA adduct formation and the efficacy of novel chemoprotective or therapeutic agents targeting oxidative pathways.
• Toxicology Studies: Essential for in vitro and in vivo research assessing the genotoxic potential of chemicals, environmental pollutants, and pharmaceuticals.
• Diagnostic Kit Development: A key component in the development and validation of ELISA and other immunoassay kits designed to measure oxidative stress markers.
• Academic Research: Fundamental reagent for university and institutional labs studying nucleic acid chemistry, repair enzymology, and the molecular basis of aging and disease.

Basic Information

Product Name	8-Hydroxy-N2-Isobutryl-2'-Deoxyguanosine
CAS No.	136859-76-2
Molecular Formula	C15H21N5O6
Molecular Weight	367.36 g/mol
Synonyms	8-OH-N2-IbdG; N2-Isobutyryl-8-hydroxy-2'-deoxyguanosine; 8-Hydroxy-dG-N2-Ibut; 8-Oxo-N2-isobutyryl-2'-deoxyguanosine; Isobutyryl-8-OHdG; 8-Hydroxy-2'-deoxyguanosine N2-isobutyrate; Modified 8-OHdG Standard; 136859-76-2
EINECS	Contact for details

Quality Control

Every batch of 8-Hydroxy-N2-Isobutryl-2'-Deoxyguanosine is manufactured and analyzed under strict quality management protocols. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, MS, and NMR characterization to ensure identity, purity, and lot-to-lot consistency suitable for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.