Description

2'-Arafluorozebularine is a fluorinated nucleoside analog, a chemically modified derivative of zebularine. This compound is of significant interest in medicinal chemistry and biochemical research due to its potential as a mechanism-based inhibitor and its role in probing enzymatic pathways. It is primarily utilized by research scientists and pharmaceutical developers in the fields of oncology, epigenetics, and antiviral drug discovery. The product is supplied to meet the stringent requirements of advanced research and development applications.

Application

• Biochemical Research: Used as a tool compound to study the mechanisms of cytidine deaminase and other nucleoside-metabolizing enzymes.
• Epigenetics & Oncology: Investigated for its potential role in DNA methylation studies and as a lead structure for developing novel epigenetic therapies.
• Antiviral Drug Development: Serves as a scaffold for designing nucleoside analogs with activity against viral polymerases.
• Medicinal Chemistry: A key intermediate for the synthesis of more complex fluorinated nucleoside derivatives with enhanced biological activity.
• Enzyme Inhibition Studies: Employed to characterize enzyme kinetics and inhibition profiles due to its fluorine substitution.
• Academic & Pharmaceutical R&D: Essential for basic research in universities and for discovery programs in biotech and pharmaceutical companies.

Basic Information

Product Name	2'-Arafluorozebularine
CAS No.	136675-88-2
Molecular Formula	C9H10FN3O5
Molecular Weight	259.19 g/mol
Synonyms	2'-Deoxy-2'-fluorozebularine; 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)pyrimidin-2(1H)-one; 2'-F-ara-Zebularine; 2'-Fluoro-2'-deoxyarabinofuranosyl-2-pyrimidinone; 2'-Fluoroarabinofuranosylzebularine; 2'-Fluorozebularine; NSC 757973
EINECS	Contact for details

Quality Control

Our 2'-Arafluorozebularine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and NMR/IR for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.