Description

Banoxantrone Dihydrochloride is a high-purity pharmaceutical intermediate and research chemical of significant interest in oncology research. This compound is valued for its role as a key precursor in the synthesis and development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers targeting the development of anti-cancer therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced anthracenedione-based anticancer drugs.
• Oncology Research: Used as a reference standard and active compound in biochemical and pharmacological studies targeting DNA topoisomerase II.
• Mechanistic Studies: Employed in vitro and in vivo to investigate the mechanisms of action, efficacy, and toxicity profiles of anthraquinone derivatives.
• Preclinical Development: Serves as a starting material for the preparation of analogs and prodrugs in early-stage drug discovery pipelines.
• Analytical Standard: Provides a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.

Basic Information

Product Name	Banoxantrone Dihydrochloride
CAS No.	136470-65-0
Molecular Formula	C₂₉H₃₄Cl₂N₄O₈ • 2HCl
Molecular Weight	678.4 g/mol (for free base C₂₉H₃₄Cl₂N₄O₈)
Synonyms	AQ4N Dihydrochloride; 1,4-Bis-{[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione Dihydrochloride; Banoxantrone HCl; NSC 709257 Dihydrochloride; Tirapazamine Analog Dihydrochloride
EINECS	Contact for details

Quality Control

Our Banoxantrone Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis, to ensure it meets stringent specifications for research and pharmaceutical use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red-brown solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.