Description

3',5-Diazido-2',3'-Dideoxyuridine is a specialized nucleoside analog derivative, a key intermediate in the synthesis of modified nucleic acids and potential antiviral agents. Its value lies in its unique azido-functionalized structure, which enables click chemistry and other bioorthogonal reactions for labeling and drug discovery applications. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors, particularly those developing novel therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Bioconjugation & Labeling: Utilized in click chemistry (e.g., CuAAC) reactions for the site-specific labeling of biomolecules like oligonucleotides and proteins.
• Probe Development: Serves as a precursor for creating fluorescent or affinity-tagged nucleotide analogs for cellular imaging and mechanistic studies.
• Antiviral Research: Investigated as a potential precursor for dideoxynucleoside analogs that may act as chain terminators in viral replication.
• Chemical Biology Tool: Enables the study of nucleic acid metabolism and the development of activity-based probes for enzyme profiling.
• Polymerase Substrate: Used in studies to understand polymerase fidelity and incorporation kinetics of modified nucleotides.

Basic Information

Product Name	3',5-Diazido-2',3'-Dideoxyuridine
CAS No.	136466-27-8
Molecular Formula	C9H8N8O4
Molecular Weight	292.21 g/mol
Synonyms	3',5-Diazido-2',3'-dideoxyuridine; 2',3'-Dideoxy-3',5-diazidouridine; 5-Azido-2',3'-dideoxy-3'-azidouridine; AZT-Azide derivative; Uridine, 2',3'-dideoxy-3',5-diazido-; 3'-Azido-3'-deoxy-5-azidouridine; 3',5-Di-azido-ddU
EINECS	Contact for details

Quality Control

Our 3',5-Diazido-2',3'-Dideoxyuridine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic and light-sensitive nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.