Description

3-Hydroxy-15-Keto-Chol-8(14)-En-24-Oic Acid is a high-purity, synthetic bile acid derivative with a defined oxo-hydroxy structure. This compound is valued as a critical intermediate or reference standard in advanced pharmaceutical research and development. It is primarily required by R&D and QC laboratories in the life sciences sector for applications in metabolic pathway studies and analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel therapeutic agents targeting metabolic and liver-related disorders.
• Reference Standard: Used for the qualitative and quantitative analysis (e.g., HPLC, LC-MS) of bile acids and related metabolites in biological samples.
• Biochemical Research: Employed in in-vitro studies to investigate bile acid receptor (FXR, TGR5) activity, signaling pathways, and enzyme interactions.
• Metabolite Standard: Acts as a calibrated standard for identifying and quantifying this specific metabolite in complex matrices during drug metabolism and pharmacokinetics (DMPK) studies.
• Process Development: Utilized in the development and optimization of synthetic routes for complex steroidal molecules within process chemistry.

Basic Information

Product Name	3-Hydroxy-15-Keto-Chol-8(14)-En-24-Oic Acid
CAS No.	136320-56-4
Molecular Formula	C24H36O4
Molecular Weight	388.54 g/mol
Synonyms	15-Keto-3α-Hydroxy-5β-chol-8(14)-en-24-oic Acid; 3α-Hydroxy-15-oxo-5β-chol-8(14)-en-24-oic Acid; 15-Ketolithocholic Acid δ8(14) Derivative; (5β)-3-Hydroxy-15-oxochol-8(14)-en-24-oic Acid; 136320-56-4; 3-Hydroxy-15-keto-5β-chol-8(14)-en-24-oic Acid
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-15-Keto-Chol-8(14)-En-24-Oic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets exacting R&D and reference standard requirements. A detailed Certificate of Analysis (COA) with batch-specific data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.