Description

Amphotericin X1 (13-o-Methyl Amphotericin B) is a chemically modified derivative of the potent polyene macrolide antifungal agent, Amphotericin B. This semi-synthetic compound is valued for its targeted biological activity and serves as a critical reference standard and intermediate in advanced pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical developers focused on antifungal drug discovery, mechanism of action studies, and the synthesis of novel therapeutic agents. The product is supplied under high-purity conditions to ensure reliability for sensitive applications.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the qualitative and quantitative analysis of amphotericin derivatives in research and quality control laboratories.
• Antifungal Research: Serves as a key intermediate or active compound in preclinical studies investigating new antifungal therapies and their mechanisms of action.
• Biochemical Research: Employed in studies exploring membrane interactions, sterol binding, and the structure-activity relationships of polyene antibiotics.
• Drug Discovery & Development: Acts as a building block or a comparative agent in the synthesis and evaluation of novel semi-synthetic antifungal candidates with potentially improved efficacy or reduced toxicity profiles.

Basic Information

Product Name	Amphotericin X1 (13-o-Methyl Amphotericin B)
CAS No.	136135-57-4
Molecular Formula	C48H75NO18
Molecular Weight	954.1 g/mol
Synonyms	13-O-Methylamphotericin B; 13-Methoxyamphotericin B; Amphotericin B 13-methyl ether; 13-OMe-AmB; (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-Amino-3,6-dideoxy-β-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
EINECS	Contact for details

Quality Control

Our Amphotericin X1 is manufactured and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the stringent requirements for research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.