Description

S4-(2-Cyanoethyl)-4-Thio-2’-Deoxyuridine is a chemically modified nucleoside analog, a critical building block in oligonucleotide synthesis and medicinal chemistry research. Its unique structure, featuring a thio-substitution and a cyanoethyl-protected group, makes it an essential reagent for the development of therapeutic nucleic acids and probes. This high-purity intermediate is primarily utilized by research institutions and pharmaceutical companies engaged in antisense oligonucleotide (ASO) development, siRNA synthesis, and diagnostic probe manufacturing.

Application

• Antisense Oligonucleotide (ASO) Synthesis: A key phosphoramidite precursor for incorporating modified bases into therapeutic oligonucleotides.
• siRNA and miRNA Research: Used in the solid-phase synthesis of RNA strands to enhance stability and target specificity.
• Diagnostic Probe Development: Serves as a modified nucleotide in fluorescent or radioactive probes for genetic testing and in-situ hybridization.
• Medicinal Chemistry & Drug Discovery: An important intermediate for creating nucleoside-based antiviral and anticancer prodrug candidates.
• Bioconjugation and Labeling: The reactive cyanoethyl and thio groups provide handles for further chemical modification and conjugation to delivery vehicles or reporter molecules.

Basic Information

Product Name	S4-(2-Cyanoethyl)-4-Thio-2’-Deoxyuridine
CAS No.	136055-15-7
Molecular Formula	C12H15N3O5S
Molecular Weight	313.33 g/mol
Synonyms	4-Thio-2'-deoxyuridine, S-(2-cyanoethyl) derivative; 2'-Deoxy-4-thiouridine, 4-(2-cyanoethylthio) derivative; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-[(2-cyanoethyl)sulfanyl]pyrimidin-2-one; 4-S-(2-Cyanoethyl)-4-thio-2'-deoxyuridine; 4-Thio-dU-CE; CE-4-Thio-dU
EINECS	Contact for details

Quality Control

Our S4-(2-Cyanoethyl)-4-Thio-2’-Deoxyuridine is manufactured under strict quality systems suitable for research and pharmaceutical intermediate applications. Every batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant internal specifications and support our customers' needs for GMP-grade materials and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.