Description

N6-Ethyl-2'-Deoxyadenosine is a chemically modified nucleoside analog of deoxyadenosine, featuring an ethyl group substitution at the N6 position of the adenine base. This specific modification is crucial for research in nucleic acid chemistry, enabling the study of base-pairing interactions, enzyme recognition, and the development of novel oligonucleotide probes. It serves as a key building block and research tool for scientists in pharmaceutical development, molecular biology, and diagnostic assay design, particularly in areas involving antisense technology and epigenetic research.

Application

• Oligonucleotide Synthesis: As a modified phosphoramidite monomer for the solid-phase synthesis of DNA and RNA analogs with altered base-pairing properties.
• Biochemical Research: Investigation of enzyme-substrate interactions, particularly with adenosine deaminases, methyltransferases, and polymerases.
• Antisense & Therapeutic Development: Incorporation into antisense oligonucleotides (ASOs) or siRNA to modulate gene expression and enhance stability.
• Diagnostic Probe Design: Used in the development of high-specificity probes for nucleic acid detection and hybridization assays.
• Structural Studies: For X-ray crystallography or NMR studies to understand the impact of base alkylation on nucleic acid duplex structure and stability.
• Epigenetics Research: As a non-natural nucleoside to study or mimic epigenetic modifications on DNA.

Basic Information

Item	Details
Product Name	N6-Ethyl-2'-Deoxyadenosine
CAS No.	136050-93-6
Molecular Formula	C12H17N5O3
Molecular Weight	279.30 g/mol
Synonyms	N6-Ethyldeoxyadenosine; 2'-Deoxy-N6-ethyladenosine; 9-(2-Deoxy-β-D-erythro-pentofuranosyl)-N6-ethyl-9H-purin-6-amine; N6-Ethyl-2'-deoxyadenosine; dA(N6-Et)
EINECS	Contact for details

Quality Control

Every batch of N6-Ethyl-2'-Deoxyadenosine is manufactured and tested under strict quality management systems. We ensure compliance with high-purity standards suitable for research and development applications. Comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, is performed to confirm identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.