Description

3′-o-Azidomethyl Dt CAS NO 136041-38-8 is a specialized nucleoside derivative, a critical building block in oligonucleotide synthesis and medicinal chemistry research. Its core value lies in its reactive azidomethyl group, which enables efficient and selective chemical modifications, particularly in the development of advanced nucleic acid therapeutics and probes. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who are developing next-generation antisense oligonucleotides, siRNA, and other targeted molecular tools.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense & siRNA Therapeutics: Used to incorporate specific modifications that enhance stability, delivery, and target affinity of therapeutic oligonucleotides.
• Click Chemistry Conjugation: The azide functional group facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling and bioconjugation.
• Diagnostic Probe Development: Enables the creation of highly specific fluorescent or affinity-tagged nucleic acid probes for detection assays.
• Medicinal Chemistry Research: Serves as a versatile intermediate in the discovery and optimization of nucleoside-based drug candidates.
• Biomaterial Functionalization: Used to attach oligonucleotides to surfaces, nanoparticles, or polymers for biosensing and tissue engineering applications.

Basic Information

Product Name	3′-o-Azidomethyl Dt
CAS No.	136041-38-8
Molecular Formula	C11H14N6O5
Molecular Weight	310.27 g/mol
Synonyms	3'-O-(Azidomethyl)thymidine; 3'-Azidomethylthymidine; 1-((2R,4S,5R)-4-Azido-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 3'-O-Azidomethyl-2'-deoxythymidine; 3'-Azidomethyl-2'-deoxythymidine; 3'-O-(N3CH2)dT; Azidomethyl-dT; N3-dT
EINECS	Contact for details

Quality Control

Our 3′-o-Azidomethyl Dt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to moisture, heat, or light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.