Description

(2-Hydroxypropyl)-β-Cyclodextrin is a chemically modified cyclodextrin derivative, widely used as a versatile solubilizing and stabilizing agent. Its primary value lies in its ability to form non-covalent inclusion complexes with a wide range of poorly soluble molecules, significantly enhancing their bioavailability, stability, and solubility in aqueous systems. This makes it an essential excipient for the pharmaceutical, food, and cosmetic industries, particularly in the formulation of injectable drugs, nutraceuticals, and flavor/fragrance delivery systems.

Application

• Pharmaceutical Formulations: As a solubility enhancer and stabilizer for injectable drugs, ophthalmic solutions, and oral dosage forms, improving the bioavailability of active pharmaceutical ingredients (APIs).
• Drug Delivery Systems: Used to create inclusion complexes for controlled release, masking of unpleasant tastes or odors, and protection of sensitive compounds from degradation.
• Food & Nutraceuticals: Employed to solubilize vitamins, flavors, colors, and other hydrophobic food additives, ensuring uniform distribution and enhanced stability in beverages and functional foods.
• Cosmetics & Personal Care: Functions as a carrier for fragrances and active ingredients in creams, lotions, and serums, improving skin penetration and formulation stability.
• Chemical & Analytical Chemistry: Serves as a chiral selector in capillary electrophoresis and HPLC for enantiomeric separation, and as a catalyst or reaction medium in organic synthesis.
• Biotechnology & Research: Used to solubilize membrane proteins for study and to enhance the activity or delivery of various biochemical reagents.

Basic Information

Product Name	(2-Hydroxypropyl)-β-Cyclodextrin
CAS No.	136019-12-0
Molecular Formula	C42H70O35 · (C3H6O)n
Molecular Weight	~1135 g/mol (base) + substitution-dependent
Synonyms	HP-β-CD; Hydroxypropyl-β-Cyclodextrin; 2-HP-β-CD; (2-Hydroxypropyl)-β-Cyclodextrin; Hydroxypropylbetadex; Kleptose® HPB; Cavasol® W7 HP; Hydroxypropyl Cyclodextrin, β-; Heptakis(2-hydroxypropyl)-β-cyclodextrin (for specific DS)
EINECS	Contact for details

Quality Control

Our (2-Hydroxypropyl)-β-Cyclodextrin is manufactured under a strict quality management system. It is available in various grades, including high-purity pharmaceutical grades compliant with major pharmacopoeias such as USP/NF, EP, and JP. Each batch undergoes rigorous analytical testing, including assay, substitution degree (DS) determination, impurity profiling, and microbiological controls. A comprehensive Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which can lead to caking or degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (HP-β-CD Content)	≥ 98.0% (on dried basis)
Substitution Degree (Molar, DS)	0.6 - 1.0 (or as specified)
Water Content (Karl Fischer)	≤ 10.0 %
Residue on Ignition (Sulfated Ash)	≤ 0.1 %
Heavy Metals (as Pb)	≤ 10 ppm
Microbiological Enumeration	Meets Ph. Eur. criteria
pH (10% solution)	5.0 - 7.5
Specific Rotation	+150° to +165°

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.