Description

2,5-Diisothiocyanatobenzenesulfonate is a specialized bifunctional chemical reagent featuring both isothiocyanate and sulfonate reactive groups. This compound matters for its unique ability to act as a versatile linker or derivatization agent in advanced material synthesis and biochemical applications. It is primarily needed by researchers and manufacturers in the pharmaceutical, bioconjugation, and polymer industries for developing targeted drug delivery systems, diagnostic probes, and functional polymers.

Application

• Bioconjugation and Protein Labeling: The isothiocyanate groups react with primary amines, making it a valuable reagent for fluorescently or chemically tagging antibodies, peptides, and other biomolecules for diagnostics and research.
• Polymer Modification and Cross-linking: Used to introduce sulfonate and reactive sites into polymer backbones, enhancing hydrophilicity, ionic character, and enabling further functionalization for specialty membranes or hydrogels.
• Chromatography Ligand Synthesis: Serves as a precursor for creating affinity chromatography media by linking to solid supports for the purification of specific proteins or enzymes.
• Material Science Intermediates: Acts as a key building block in synthesizing advanced organic materials, including metal-organic frameworks (MOFs) and conductive polymers, where its dual functionality is leveraged.
• Diagnostic Reagent Manufacturing: Employed in the production of chemical components for immunoassays and other clinical diagnostic kits.
• Research & Development: A critical tool in academic and industrial R&D for exploring new synthetic pathways and creating novel chemical entities with tailored properties.

Basic Information

Product Name	2,5-Diisothiocyanatobenzenesulfonate
CAS No.	135705-08-7
Molecular Formula	C8H4N2O3S3
Molecular Weight	272.32 g/mol
Synonyms	1,4-Diisothiocyanatobenzene-2-sulfonate; 2,5-Diisothiocyanatobenzenesulfonic Acid; Benzenesulfonic acid, 2,5-diisothiocyanato-; 2,5-Diisothiocyanatobenzene-1-sulfonate; 2,5-Diisothiocyanato-1-sulfobenzene; DIDS sulfonate analog; Bifunctional isothiocyanate sulfonate linker
EINECS	Contact for details

Quality Control

Every batch of 2,5-Diisothiocyanatobenzenesulfonate undergoes rigorous analytical testing to ensure high purity and consistent performance. Our quality assurance protocols are designed to meet the stringent requirements of research and industrial applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMF, DMSO; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.