Description

Remikiren is a potent and selective renin inhibitor, representing a significant class of compounds for cardiovascular research. This high-purity reference standard is essential for pharmaceutical development, enabling precise biochemical and pharmacological studies. It is primarily utilized by research institutions and pharmaceutical companies focused on developing novel antihypertensive therapies and studying the renin-angiotensin system.

Application

• Pharmaceutical R&D: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel antihypertensive drugs.
• Biochemical Research: Used as a specific tool compound to study the inhibition kinetics and mechanism of action of human renin in enzymatic assays.
• Preclinical Studies: Employed in animal models to investigate the efficacy, pharmacokinetics, and pharmacodynamics of renin inhibition for blood pressure regulation.
• Analytical Method Development: Acts as a primary standard for calibrating HPLC, LC-MS, and other analytical methods used in quality control and metabolic studies.
• Structure-Activity Relationship (SAR) Studies: Provides a core molecular scaffold for medicinal chemists to design and synthesize new analogs with improved potency and selectivity.

Basic Information

Product Name	Remikiren
CAS No.	135669-48-6
Molecular Formula	C30H41N3O4
Molecular Weight	507.67 g/mol
Synonyms	Ro 42-5892; (2S,4S,5S)-5-[(N-[(1S)-3-Amino-1-(cyclohexylmethyl)-2,3-dioxopropyl]-L-leucyl]amino]-4-hydroxy-2-isopropyl-6-methyl-N-[1-(4-morpholinylcarbonyl)-3-phenylpropyl]heptanamide; Remikirenum; Remikireno; Remikirenum
EINECS	Contact for details

Quality Control

Our Remikiren is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.