Description

2'-Deoxy-5-Iodouridine 5'-(4-Nitrobenzoate) is a chemically modified nucleoside derivative, serving as a crucial synthetic intermediate and research reagent. This compound is valued for its role in the synthesis of more complex nucleoside analogs and as a biochemical tool for studying nucleic acid structure and function. It is primarily utilized by pharmaceutical R&D teams, academic research laboratories, and specialty chemical manufacturers focused on antiviral drug development and nucleotide chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA/RNA metabolism and polymerase activity.
• Pro-drug Development: The 4-nitrobenzoate protecting group makes it a precursor for developing prodrug strategies to enhance drug delivery and bioavailability.
• Radiopharmaceutical Precursor: The iodine atom provides a potential site for radioiodination, useful in developing diagnostic imaging agents.
• Organic Synthesis: Employed in synthetic organic chemistry for constructing modified oligonucleotides or exploring new coupling reactions.
• Academic & Industrial R&D: Serves as a standard or reference compound in method development and quality control for nucleotide-based products.

Basic Information

Product Name	2'-Deoxy-5-Iodouridine 5'-(4-Nitrobenzoate)
CAS No.	135617-14-0
Molecular Formula	C16H14IN3O8
Molecular Weight	503.21 g/mol
Synonyms	5-Iodo-2'-deoxyuridine 5'-(4-nitrobenzoate); 5-Iodo-2'-deoxyuridine 5'-mono(4-nitrobenzoate); 2'-Deoxy-5-iodouridine 5'-p-nitrobenzoate; IDU 5'-(4-Nitrobenzoate); 5-Iododeoxyuridine 5'-(4-nitrobenzoate); p-Nitrobenzoyl-5-iodo-2'-deoxyuridine; 135617-14-0
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-5-Iodouridine 5'-(4-Nitrobenzoate) is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing batch-specific results is provided to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, the container should be kept sealed under anhydrous conditions if possible.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.