Description

(2R,3R,4S,5R)-5-(6-Benzamido-9H-Purin-9-Yl)-2-((Benzoyloxy)Methyl)-4-Fluorotetrahydrofuran-3-Yl Benzoate (Wxc03257) is a high-purity, structurally complex nucleoside analog derivative. This compound matters as a critical advanced intermediate in pharmaceutical research and development, particularly for the synthesis of novel antiviral and anticancer agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries working on nucleoside-based therapeutics.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of modified nucleoside analogs with potential antiviral or anticancer activity.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Oncology Research: Serves as a precursor for investigational chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Biochemical Tool: Employed in enzymatic studies and as a substrate analog to investigate the mechanisms of nucleoside-processing enzymes.
• Process Chemistry: Utilized in route scouting and scale-up optimization for the manufacture of complex active pharmaceutical ingredients (APIs).
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs offering bespoke chemical synthesis services.

Basic Information

Item	Details
Product Name	(2R,3R,4S,5R)-5-(6-Benzamido-9H-Purin-9-Yl)-2-((Benzoyloxy)Methyl)-4-Fluorotetrahydrofuran-3-Yl Benzoate (Wxc03257)
CAS No.	135473-17-5
Molecular Formula	C31H24FN5O6
Molecular Weight	581.55 g/mol
Synonyms	9-[(2R,3R,4S,5R)-3,5-Bis(benzoyloxy)-4-fluoro-2-(hydroxymethyl)tetrahydrofuran-2-yl]-N-benzoyladenine; 2'-Deoxy-2'-fluoro-5'-O-benzoyl-3'-O-benzoyl-N6-benzoyladenosine; 2'-Fluoro-5',3'-di-O-benzoyl-N6-benzoyl-2'-deoxyadenosine; 1-(2-Deoxy-2-fluoro-3,5-di-O-benzoyl-β-D-erythro-pentofuranosyl)-N-benzoyladenine; N6,5',3'-Tri-O-benzoyl-2'-deoxy-2'-fluoroadenosine; 2'-F-dA(Bz) amidite precursor; FLT intermediate; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our (2R,3R,4S,5R)-5-(6-Benzamido-9H-Purin-9-Yl)-2-((Benzoyloxy)Methyl)-4-Fluorotetrahydrofuran-3-Yl Benzoate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Chiral Purity	≥ 99.0% ee
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.