Description

Ethyl 2-(3-Chlorophenyl)-2,2-Difluoroacetate is a high-value fluorinated organic building block, essential for introducing the difluoroacetate moiety into complex molecular architectures. This compound is critical for fine chemical synthesis, offering a versatile handle for constructing advanced intermediates in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a difluoromethyl or difluoroacetate functional group.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides where fluorination enhances biological activity and stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated components in liquid crystal displays (LCDs) due to its influence on dielectric anisotropy and viscosity.
• Organic Electronics: Employed in the synthesis of monomers and precursors for specialty polymers used in organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research: A versatile reagent in academic and industrial laboratories for exploring new fluorination methodologies and creating novel fluorinated compounds.
• Custom Synthesis: Foundation for contract research and manufacturing organizations (CROs/CMOs) to produce bespoke intermediates for client projects.

Basic Information

Product Name	Ethyl 2-(3-Chlorophenyl)-2,2-Difluoroacetate
CAS No.	135334-14-4
Molecular Formula	C10H9ClF2O2
Molecular Weight	234.63 g/mol
Synonyms	Ethyl 3-Chloro-α,α-difluorobenzeneacetate; 2-(3-Chlorophenyl)-2,2-Difluoroacetic Acid Ethyl Ester; Ethyl 2,2-Difluoro-2-(3-chlorophenyl)acetate; 3-Chloro-α,α-difluorobenzeneacetic Acid Ethyl Ester; Difluoro(3-chlorophenyl)acetic Acid Ethyl Ester; Ethyl (3-Chlorophenyl)difluoroacetate; NSC 405124; Ethyl α,α-Difluoro-3-chlorophenylacetate
EINECS	Contact for details

Quality Control

Our Ethyl 2-(3-Chlorophenyl)-2,2-Difluoroacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.