Description

(2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butane-2,3-Diol is a high-purity chiral intermediate of significant importance in the synthesis of advanced active pharmaceutical ingredients (APIs). This compound matters because its specific stereochemistry is critical for the biological activity and efficacy of the final drug product, making it a key building block for pharmaceutical manufacturers. It is primarily needed by R&D laboratories and production facilities in the pharmaceutical and agrochemical industries for developing and producing novel triazole-based antifungal agents and other specialized fine chemicals.

Application

• Key chiral intermediate in the synthesis of potent triazole antifungal APIs.
• Research and development of new pharmaceutical candidates targeting fungal infections.
• Agrochemical synthesis for developing novel fungicides with specific stereochemical activity.
• Process chemistry and scale-up studies for pharmaceutical manufacturing.
• Reference standard for analytical method development and quality control in API production.
• Building block for specialized fine chemicals and other bioactive molecules.

Basic Information

Product Name	(2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butane-2,3-Diol
CAS No.	135272-36-5
Molecular Formula	C₁₂H₁₃F₂N₃O₂
Molecular Weight	269.25 g/mol
Synonyms	(2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butane-2,3-diol; (2S,3R)-2-(2,4-Difluorophenyl)-1-(1,2,4-triazol-1-yl)butane-2,3-diol; Voriconazole Intermediate; UK-109496 Intermediate; (2R,3S)-2-(2,4-Difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)butane-1,2-diol (enantiomer); Difluorophenyl Triazole Diol; 1-(1H-1,2,4-Triazol-1-yl)-2-(2,4-difluorophenyl)-2,3-butanediol (stereoisomer mixture)
EINECS	Contact for details

Quality Control

Our (2S,3R)-2-(2,4-Difluorophenyl)-1-(1H-1,2,4-Triazol-1-Yl)Butane-2,3-Diol is manufactured under strict quality systems to ensure high chemical and stereochemical purity, suitable for pharmaceutical applications. Each batch undergoes rigorous analytical testing, including HPLC for assay and enantiomeric excess (e.e.) determination, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.