Description

2’-Deoxy-2’-Fluoro-5-Methyl-4’-Thio-β-D-Arabinouridine is a high-purity, modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate and building block in the creation of novel therapeutic agents, particularly antiviral and anticancer drugs. It is primarily utilized by research institutions, pharmaceutical companies, and CDMOs engaged in the synthesis of nucleoside-based prodrugs and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Antiviral Drug Research: Used in the development of therapeutics targeting viruses such as hepatitis and influenza.
• Oncology Research: Serves as a precursor in the design of chemotherapeutic agents that interfere with DNA/RNA synthesis in cancer cells.
• Prodrug Synthesis: Employed in the creation of prodrugs designed for improved bioavailability and targeted delivery.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand cellular processes.
• Process Development: Supports scale-up and optimization of synthetic routes for GMP manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2’-Deoxy-2’-Fluoro-5-Methyl-4’-Thio-β-D-Arabinouridine
CAS No.	135123-34-1
Molecular Formula	C10H13FN2O4S
Molecular Weight	276.29 g/mol
Synonyms	4'-Thio-2'-deoxy-2'-fluoro-5-methyl-β-D-arabinouridine; 2'-Fluoro-5-methyl-4'-thioarabinouridine; 2'-F-5-Me-4'-thio-araU; 5-Methyl-2'-deoxy-2'-fluoro-4'-thio-β-D-arabinofuranosyluracil; 4'-Thio-FMAU; 2'-F-5-Me-4'-thio-β-D-arabino-U; 135123-34-1; 2'-Deoxy-2'-fluoro-5-methyl-4'-thio-β-D-arabinouridine
EINECS	Contact for details

Quality Control

Our 2’-Deoxy-2’-Fluoro-5-Methyl-4’-Thio-β-D-Arabinouridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.