Description

4-Benzyl-2-Morpholinecarbonyl Chloride Hydrochloride is a high-purity, reactive chemical intermediate primarily used in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring a reliable building block for constructing complex molecules, particularly in pharmaceutical development. Its primary value lies in enabling the efficient introduction of the 4-benzyl-2-morpholinecarbonyl moiety under controlled conditions, making it essential for medicinal chemistry, process R&D, and fine chemical production targeting regulated markets.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly those targeting neurological and metabolic disorders.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to develop new pharmacophores.
• Peptide Mimetic Synthesis: Employed in the creation of peptidomimetics and constrained analogs where the morpholine ring provides favorable pharmacokinetic properties.
• Agrochemical Development: Intermediate in the research and production of advanced herbicides and fungicides.
• Ligand and Catalyst Preparation: Serves as a precursor for specialized ligands used in asymmetric catalysis and metal complex formation.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production.

Basic Information

Product Name	4-Benzyl-2-Morpholinecarbonyl Chloride Hydrochloride
CAS No.	135072-14-9
Molecular Formula	C₁₃H₁₅Cl₂NO₂
Molecular Weight	288.17 g/mol
Synonyms	4-Benzylmorpholine-2-carbonyl chloride hydrochloride; 2-Morpholinecarbonyl chloride, 4-benzyl-, hydrochloride; 4-Benzyl-2-morpholinecarboxylic acid chloride hydrochloride; 4-Benzylmorpholine-2-carboxylic acid chloride hydrochloride; 4-Benzyl-2-chlorocarbonylmorpholine hydrochloride; 2-(Chlorocarbonyl)-4-benzylmorpholine hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Benzyl-2-Morpholinecarbonyl Chloride Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets exacting standards for research and production. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.