Description

3-Isoisoguanosine 5'-Phospho-2-Methylimidazole is a high-purity, modified nucleoside derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical building block and research tool for studying nucleic acid chemistry, enzyme mechanisms, and for the synthesis of novel nucleotide analogs. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in areas such as antiviral drug discovery, oligonucleotide synthesis, and the development of diagnostic probes. Its unique structure makes it valuable for exploring novel therapeutic pathways and biochemical interactions.

Application

• Biochemical Research: Used as a specialized substrate or inhibitor in enzymatic studies, particularly those involving kinases, polymerases, and other nucleotide-processing enzymes.
• Antiviral Drug Discovery: Serves as a key intermediate or analog in the synthesis and screening of novel nucleoside-based antiviral agents targeting viral replication.
• Oligonucleotide Synthesis: Employed as a modified phosphoramidite or solid-phase synthesis building block for creating non-canonical oligonucleotides with altered properties for research and diagnostics.
• Diagnostic Probe Development: Utilized in the design and construction of labeled probes for detecting specific DNA/RNA sequences or studying nucleic acid-protein interactions.
• Enzyme Mechanism Studies: Acts as a tool compound to investigate the binding pockets and catalytic mechanisms of purine and nucleotide-binding proteins.
• Medicinal Chemistry: Provides a versatile scaffold for medicinal chemists to develop new chemical entities with potential therapeutic applications in oncology and virology.

Basic Information

Product Name	3-Isoisoguanosine 5'-Phospho-2-Methylimidazole
CAS No.	135052-69-6
Molecular Formula	C14H18N6O8P
Molecular Weight	429.30 g/mol
Synonyms	5'-O-Phosphono-3-isoisoguanosine 2-methylimidazolide; 2-Methylimidazolide of 3-Isoisoguanosine 5'-Monophosphate; 3-Isoisoguanosine 5'-Monophospho-2-methylimidazolide; 3-Iso-GMP-Imidazolide; 2-Methyl-1H-imidazol-1-yl 3-Isoisoguanosine 5'-(dihydrogen phosphate); Isoisoguanosine phosphorimidazolide; 3-Isoisoguanilyl-2-methylimidazolide 5'-phosphate
EINECS	Contact for details

Quality Control

Our 3-Isoisoguanosine 5'-Phospho-2-Methylimidazole is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet the exacting standards of research-grade materials, specifications can be aligned with specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.