Description

2'-o-Methyl-N2-Methylguanosine is a chemically modified nucleoside derivative, specifically a methylated analog of guanosine. This compound is of significant value in the research and development of oligonucleotide therapeutics, where it serves as a critical building block to enhance stability and modulate biological activity. It is primarily needed by biotechnology and pharmaceutical companies engaged in the synthesis of antisense oligonucleotides, siRNA, and other advanced nucleic acid-based drugs.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of therapeutic and diagnostic oligonucleotides.
• Antisense Technology: Used to incorporate modifications that improve nuclease resistance and target affinity in antisense oligonucleotides.
• RNA Interference (RNAi): Employed in the design and manufacture of siRNA duplexes to enhance stability and pharmacokinetic properties.
• Structural Biology Research: Serves as a probe to study RNA structure, function, and protein-RNA interactions.
• Pharmaceutical R&D: A vital raw material in the discovery and preclinical development of novel nucleic acid therapeutics.
• Diagnostic Probe Development: Utilized in creating modified probes for sensitive and specific molecular detection assays.

Basic Information

Product Name	2'-o-Methyl-N2-Methylguanosine
CAS No.	135023-21-1
Molecular Formula	C12H17N5O5
Molecular Weight	311.30 g/mol
Synonyms	2'-O-Methyl-N2-methylguanosine; N2-Methyl-2'-O-methylguanosine; 9-[(2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-methyloxolan-2-yl]-2-(methylamino)-1H-purin-6-one; 2'-O-Me-N2-Me-Guo; 2'-O-Methyl-N(2)-methylguanosine; N2,2'-O-Dimethylguanosine
EINECS	Contact for details

Quality Control

Our 2'-o-Methyl-N2-Methylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with the stringent requirements of pharmaceutical and biotech applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.