Description

3-(7 β-Hydroxycholesteryl) 5'-Thymidylyl Monophosphate is a specialized nucleotide-lipid conjugate, a key building block in advanced biochemical research and pharmaceutical development. This compound is valued for its unique structure, which combines a nucleoside monophosphate with a sterol moiety, enabling its use in creating novel biomimetic materials and targeted delivery systems. It is primarily sought by researchers and developers in the fields of nucleic acid chemistry, lipid nanoparticle (LNP) formulation, and prodrug synthesis for therapeutic applications.

Application

• Lipid Nanoparticle (LNP) Research: As a functionalized lipid component for the development and optimization of next-generation delivery vehicles for mRNA, siRNA, and other nucleic acid therapeutics.
• Prodrug Development: Serving as a synthetic intermediate for creating nucleotide prodrugs with enhanced cellular uptake and targeted release profiles.
• Bioconjugation & Labeling: Used in the synthesis of cholesterol-tagged oligonucleotides for cellular tracking, membrane association studies, and diagnostic probe development.
• Biomimetic Membrane Studies: Incorporated into liposomes and other model membrane systems to study the interaction of nucleic acids with lipid bilayers.
• Antiviral & Anticancer Research: Investigated as a precursor for novel therapeutic agents that interfere with viral replication or cellular signaling pathways.
• Chemical Biology Tool: Employed in exploring enzyme mechanisms and metabolic pathways involving nucleotide and sterol metabolism.

Basic Information

Item	Detail
Product Name	3-(7 β-Hydroxycholesteryl) 5'-Thymidylyl Monophosphate
CAS No.	134917-45-6
Molecular Formula	C37H59N2O9P
Molecular Weight	706.85 g/mol
Synonyms	3-(7β-Hydroxycholesteryl) Thymidine 5'-Monophosphate; 3-(7β-Hydroxycholest-5-en-3β-yl) Thymidine 5'-Monophosphate; Cholesterol-Modified Thymidine Monophosphate; 5'-TMP-Cholesterol Conjugate; Thymidylyl Monophosphate Cholesteryl Ester; Nucleotide-Sterol Conjugate; 3-(7β-Hydroxycholesteryl)-5'-TMP; 3-(7β-Hydroxycholest-5-en-3β-yloxycarbonyl)propyl Thymidine 5'-Monophosphate
EINECS	Contact for details

Quality Control

Our production of 3-(7 β-Hydroxycholesteryl) 5'-Thymidylyl Monophosphate adheres to stringent in-house quality protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.