Description

5'-Deoxy-5'-((2-Monofluoroethyl)Thio)Adenosine is a chemically modified nucleoside analog, a key building block in medicinal chemistry and biochemical research. Its unique structure, featuring a deoxyribose sugar modified with a monofluoroethylthio group at the 5' position, makes it a valuable intermediate for the synthesis of novel therapeutic agents and research probes. This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing nucleoside-based drugs, enzyme inhibitors, and diagnostic tools.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving adenosine-processing enzymes.
• Proteomics & Molecular Biology: Serves as a building block for labeling reagents or affinity probes to study protein-nucleic acid interactions.
• Radiopharmaceutical Development: Potential precursor for the synthesis of fluorinated tracers used in Positron Emission Tomography (PET) imaging.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by introducing fluorine and sulfur modifications to adenosine scaffolds.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing of high-value, complex organic molecules.

Basic Information

Product Name	5'-Deoxy-5'-((2-Monofluoroethyl)Thio)Adenosine
CAS No.	134782-20-0
Molecular Formula	C₁₃H₁₈FN₅O₃S
Molecular Weight	343.38 g/mol
Synonyms	5'-Deoxy-5'-[(2-fluoroethyl)thio]adenosine; 5'-S-(2-Fluoroethyl)-5'-thioadenosine; 2-Fluoroethylthioadenosine; 5'-Deoxy-5'-(2-fluoroethylthio)adenosine; Adenosine, 5'-deoxy-5'-[(2-fluoroethyl)thio]-; 5'-Deoxy-5'-[(2-fluoroethyl)sulfanyl]adenosine
EINECS	Contact for details

Quality Control

Our 5'-Deoxy-5'-((2-Monofluoroethyl)Thio)Adenosine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.