Description

(2R,3R)-2-(2,4-Difluorophenyl)-3-Methylsulfonyl-1-(1,2,4-Triazol-1-Yl)Butan-2-Ol is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced pharmaceutical synthesis. This compound matters because its specific (2R,3R) stereochemistry is critical for imparting the desired biological activity and efficacy in final active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development and production of novel triazole-based antifungal and therapeutic agents.

Application

• Key Intermediate in Antifungal API Synthesis: Serves as a crucial chiral building block for the production of advanced triazole antifungal drugs, such as those in the echinocandin or broad-spectrum antifungal classes.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and structure-activity relationship (SAR) studies of new therapeutic candidates targeting fungal infections.
• Agrochemical Active Ingredient Production: Employed in the synthesis of modern triazole-based fungicides, contributing to crop protection solutions.
• Process Chemistry & Scale-Up: Utilized in process optimization and pilot-scale manufacturing of complex molecules requiring high stereochemical fidelity.
• Reference Standard: Acts as a certified reference material (CRM) for quality control and analytical method development in regulatory-compliant laboratories.

Basic Information

Product Name	(2R,3R)-2-(2,4-Difluorophenyl)-3-Methylsulfonyl-1-(1,2,4-Triazol-1-Yl)Butan-2-Ol
CAS No.	134779-41-2
Molecular Formula	C₁₃H₁₅F₂N₃O₃S
Molecular Weight	331.34 g/mol
Synonyms	(2R,3R)-2-(2,4-Difluorophenyl)-3-(methylsulfonyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; (2R,3R)-Epoxiconazole Alcohol; (2R,3R)-Epoxiconazole Intermediate; (2R,3R)-2-(2,4-Difluorophenyl)-3-methylsulfonyl-1-(1,2,4-triazol-1-yl)butan-2-ol; Epoxiconazole Key Chiral Synthon; 1H-1,2,4-Triazole, 1-[(2R,3R)-3-[(methylsulfonyl)methyl]-2-(2,4-difluorophenyl)oxiranyl]-, (rel)-; (rel)-(2R,3R)-Epoxiconazole Alcohol
EINECS	Contact for details

Quality Control

Our (2R,3R)-2-(2,4-Difluorophenyl)-3-Methylsulfonyl-1-(1,2,4-Triazol-1-Yl)Butan-2-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC to confirm stereochemical purity and identity. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2R,3R)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.