Description

Clofarabine Triphosphate is the active triphosphate metabolite of the nucleoside analog prodrug Clofarabine, a key intermediate in its mechanism of action. This compound is of critical importance for pharmaceutical research and development, particularly in the study of antimetabolite therapies. It is primarily utilized by research scientists and pharmaceutical developers in the fields of oncology research, drug metabolism studies, and biochemical assay development.

Application

• Biochemical Research: Used as a substrate or reference standard in enzymatic studies related to DNA synthesis and repair mechanisms.
• Oncology Drug Development: Serves as a critical intermediate for investigating the intracellular activation and efficacy of Clofarabine and related nucleoside analogs.
• Metabolite Identification: Employed as an analytical standard in LC-MS or HPLC methods to identify and quantify active metabolites in pharmacokinetic studies.
• Enzyme Kinetics: Utilized in assays to study the activity of kinases and other enzymes involved in nucleotide metabolism.
• Cell-Based Assays: Applied in research to understand the cytotoxic effects and mechanism of action of activated nucleoside drugs in cancer cell lines.
• Reference Material Production: Sourced by manufacturers of certified reference materials (CRMs) for quality control in pharmaceutical analysis.

Basic Information

Product Name	Clofarabine Triphosphate
CAS No.	134646-41-6
Molecular Formula	C10H16ClN5O12P3
Molecular Weight	583.66 g/mol
Synonyms	2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine 5'-triphosphate; 2-Cl-2'-fluoro-arabinofuranosyl-adenine triphosphate; 2-Chloro-2'-fluoro-arabinofuranosyladenine triphosphate; Cl-F-ara-ATP; Clofarabine 5'-triphosphate; 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-2-chloro-adenine 5'-triphosphate; 2-Chloro-2'-deoxy-2'-fluoro-9-β-D-arabinofuranosyladenine 5'-triphosphate
EINECS	Contact for details

Quality Control

Our Clofarabine Triphosphate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.