Description

Adenosine, 2'-Deoxy-2'-Fluoro-n-Methyl- is a chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a key synthetic intermediate and building block in the creation of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleotide-based therapies and diagnostic probes.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of modified oligonucleotides and nucleotide-based prodrugs.
• Antiviral Drug Research: Used in the development of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral compounds targeting viral polymerases.
• Oncology Research: Serves as a precursor in the creation of chemotherapeutic agents designed to interfere with cancer cell DNA/RNA synthesis.
• Biochemical Tool: Employed in mechanistic studies of enzyme kinetics, particularly those involving adenosine deaminase or kinase enzymes.
• Diagnostic Probe Development: Utilized in the design of labeled nucleotides for molecular imaging and diagnostic assays.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize drug potency and metabolic stability.

Basic Information

Product Name	Adenosine, 2'-Deoxy-2'-Fluoro-n-Methyl-
CAS No.	134444-58-9
Molecular Formula	C11H14FN5O3
Molecular Weight	283.26 g/mol
Synonyms	2'-Deoxy-2'-fluoro-N-methyladenosine; 9-[(2R,3R,4S,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-6-aminopurine; N-Methyl-2'-deoxy-2'-fluoroadenosine; 2'-F-2'-d-N-Me-Ado; 2'-Fluoro-2'-deoxy-N-methyladenosine; 1-Methyl-2'-deoxy-2'-fluoroadenosine (tautomeric form); Adenosine, 2'-deoxy-2'-fluoro-N-methyl-
EINECS	Contact for details

Quality Control

Our Adenosine, 2'-Deoxy-2'-Fluoro-n-Methyl- is produced under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity suitable for research applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles by HPLC are provided with each shipment. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 98.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.