Description

2-Amino-2'-Deoxy-2'-Fluoro-D-Adenosine is a high-purity nucleoside analog, a critical building block in advanced pharmaceutical and biochemical research. Its modified sugar moiety, featuring a fluorine atom at the 2' position, makes it a valuable precursor for the synthesis of oligonucleotides with enhanced stability and specific biological activity. This compound is essential for researchers and manufacturers in the fields of antiviral drug development, antisense oligonucleotide therapeutics, and diagnostic probe synthesis.

Application

• Antiviral Drug Development: Key intermediate in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Antisense Oligonucleotide (ASO) Synthesis: Used to incorporate modified bases into oligonucleotides to enhance target binding affinity and nuclease resistance.
• siRNA and miRNA Research: Serves as a crucial raw material for constructing chemically modified small interfering RNA (siRNA) and microRNA (miRNA) strands to improve pharmacokinetic properties.
• Diagnostic Probe Manufacturing: Employed in the production of labeled nucleotides for fluorescence in situ hybridization (FISH) and other molecular diagnostic assays.
• Medicinal Chemistry & Lead Optimization: A versatile scaffold for structure-activity relationship (SAR) studies in drug discovery programs targeting various enzymes and receptors.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleic acid metabolism and related pathways.

Basic Information

Item	Details
Product Name	2-Amino-2'-Deoxy-2'-Fluoro-D-Adenosine
CAS No.	134444-47-6
Molecular Formula	C10H13FN6O3
Molecular Weight	284.25 g/mol
Synonyms	2'-Fluoro-2'-deoxy-2-aminoadenosine; 2-Amino-9-(2-deoxy-2-fluoro-β-D-ribofuranosyl)adenine; 2-Fluoro-2'-deoxy-2-aminoadenosine; 2'-F-2-NH2-dA; 2'-Fluoro-2-aminoadenosine; 2-Amino-2'-fluoro-2'-deoxyadenosine; 9-[(2R,3R,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-aminopurin-6-one
EINECS	Contact for details

Quality Control

Our 2-Amino-2'-Deoxy-2'-Fluoro-D-Adenosine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under a dry, inert atmosphere or in a desiccator to prevent degradation. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.