Description

1-Pyrrolidinecarbonyl Chloride, 2,5-Dioxo- (9Ci) is a highly reactive acid chloride derivative of a pyrrolidine-dione (succinimide) scaffold. This compound matters as a critical building block for introducing the N-(chlorocarbonyl)succinimide moiety, enabling the synthesis of complex molecules and functional materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs), particularly for compounds containing modified amino acid or heterocyclic structures.
• Peptide Mimetic & Conjugate Synthesis: Used to create peptide-like molecules or to conjugate pharmacophores to carriers, leveraging its reactive carbonyl chloride group.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, or plant growth regulators that incorporate the succinimide functional group.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing specialty polymers with tailored thermal or mechanical properties.
• Chemical Biology Probes: Utilized to create affinity labels or activity-based probes for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses serving the life sciences sector, where precise molecular construction is required.

Basic Information

Item	Detail
Product Name	1-Pyrrolidinecarbonyl Chloride, 2,5-Dioxo- (9Ci)
CAS No.	134402-80-5
Molecular Formula	C5H4ClNO3
Molecular Weight	161.54 g/mol
Synonyms	N-(Chlorocarbonyl)succinimide; Succinimidocarbonyl chloride; 2,5-Dioxo-1-pyrrolidinecarbonyl chloride; 1-(Chlorocarbonyl)-2,5-pyrrolidinedione; NSC 401119; Succinimido carbonyl chloride; N-Succinimidyl chloroformate (related); N-Succinimidyl carbonochloridate (related)
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarbonyl Chloride, 2,5-Dioxo- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.