Description

5-(5-Bromothien-2-Yl)-2'-Deoxyuridine is a modified nucleoside analog, a key building block in medicinal chemistry and life science research. This compound matters for its role as a versatile intermediate in the synthesis of novel antiviral and anticancer agents, particularly those targeting viral polymerases and cellular DNA replication. Researchers and pharmaceutical developers in the fields of antiviral drug discovery, oncology research, and nucleotide chemistry require this high-purity intermediate to advance their therapeutic programs.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Antiviral Research: Used in the development of compounds targeting herpesviruses, hepatitis B virus (HBV), and other DNA viruses.
• Oncology Drug Discovery: Serves as a precursor for thymidine analogs that act as antimetabolites to inhibit cancer cell proliferation.
• Biochemical Probe: Utilized in studies of DNA synthesis, polymerase enzyme mechanisms, and nucleotide metabolism.
• Labeled Compound Synthesis: A starting material for preparing radiolabeled (e.g., tritiated) or fluorescently tagged nucleosides for diagnostic and tracking applications.
• Academic & Contract Research: Essential reagent for universities and CROs conducting fundamental research in medicinal chemistry and molecular biology.

Basic Information

Product Name	5-(5-Bromothien-2-Yl)-2'-Deoxyuridine
CAS No.	134333-70-3
Molecular Formula	C13H13BrN2O5S
Molecular Weight	389.22 g/mol
Synonyms	5-(5-Bromothiophen-2-yl)-2'-deoxyuridine; 5-(5-Bromo-2-thienyl)-2'-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(5-bromothiophen-2-yl)pyrimidine-2,4-dione; 2'-Deoxy-5-(5-bromo-2-thienyl)uridine; BrdUrd Thiophene Analog; 5-Bromothienyl-dU
EINECS	Contact for details

Quality Control

Our 5-(5-Bromothien-2-Yl)-2'-Deoxyuridine is manufactured under controlled conditions to ensure high chemical purity and batch-to-batch consistency, suitable for research and development applications. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.