Description

5'-o-(tert-Butyldimethylsilyl)-5-Iodo-2'-Deoxyuridine is a key nucleoside derivative, specifically a silyl-protected and halogenated analog of deoxyuridine, widely used as a critical building block in synthetic organic chemistry and pharmaceutical research. Its primary value lies in its role as a versatile intermediate for the synthesis of modified oligonucleotides, antiviral agents, and radio-labeled compounds for diagnostic applications. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic reagent sectors who require reliable, high-quality building blocks for complex molecular synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used to introduce modified bases into DNA/RNA sequences for research, diagnostics, and therapeutic oligonucleotides (e.g., antisense, siRNA).
• Radiolabeling Precursor: Serves as a starting material for the preparation of iodine-125 (125I) labeled compounds used in radioimmunoassays and imaging studies.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to develop new therapeutic agents targeting viral polymerases and cellular enzymes.
• Bioconjugation: The reactive iodine moiety allows for further functionalization and conjugation to biomolecules, peptides, or solid supports.
• Process Chemistry: Used in the scalable production of active pharmaceutical ingredients (APIs) requiring specific nucleoside modifications.

Basic Information

Item	Details
Product Name	5'-o-(tert-Butyldimethylsilyl)-5-Iodo-2'-Deoxyuridine
CAS No.	134218-81-8
Molecular Formula	C15H25IN2O5Si
Molecular Weight	468.27 g/mol
Synonyms	5-Iodo-2'-deoxyuridine 5'-(tert-butyldimethylsilyl) ether; 5-Iodo-1-[(2R,4S,5R)-4-hydroxy-5-[[(1,1-dimethylethyl)dimethylsilyl]oxymethyl]tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione; 5-Iodo-2'-deoxyuridine 5'-TBDMS ether; 5-Iododeoxyuridine 5'-O-(tert-butyldimethylsilyl) ether; TBDMS-5-Iodo-dU; 5-Iodo-dU TBDMS; 5-I-2'-dU 5'-O-TBDMS
EINECS	Contact for details

Quality Control

Our 5'-o-(tert-Butyldimethylsilyl)-5-Iodo-2'-Deoxyuridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity (HPLC), identity (NMR, IR), and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.