Description

9H-Purin-6-Amine, 9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)-2-Fluoro- is a high-purity fluorinated nucleoside analog, a critical building block in advanced pharmaceutical research and development. This compound is valued for its role as a key intermediate in the synthesis of novel antiviral and anticancer therapeutics, particularly those targeting viral polymerases and cellular DNA/RNA metabolism. It is essential for R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and biotechnology sectors seeking to develop next-generation nucleoside-based drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) for antiviral and anticancer medications.
• Antiviral Drug Research: Used in the development of nucleoside analogs targeting viruses such as hepatitis B virus (HBV), hepatitis C virus (HCV), and other viral pathogens.
• Oncology Research: Serves as a building block for creating chemotherapeutic agents that interfere with cancer cell proliferation.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor to investigate nucleoside-metabolizing enzymes.
• Process Chemistry & Scale-Up: Utilized in route development and optimization for the commercial-scale manufacturing of fluorinated nucleosides.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Product Name	9H-Purin-6-Amine, 9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)-2-Fluoro-
CAS No.	134217-15-5
Molecular Formula	C₁₀H₁₁F₂N₅O₃
Molecular Weight	287.22 g/mol
Synonyms	2'-Fluoro-2'-deoxy-β-D-arabinofuranosyl-2-fluoroadenine; 2-Fluoro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine; 2'-F-2'-deoxy-β-D-arabinofuranosyl-2-F-Ade; 2-Fluoro-ara-2'-deoxy-2'-fluoroadenosine; F-ara-2'-F-adenosine; 2-F-2'-F-araA; 2-Fluoro-2'-deoxy-β-D-arabinofuranosyladenine (2-fluoro analog); β-2'-Fluoro-2'-deoxyarabinofuranosyl-2-fluoroadenine
EINECS	Contact for details

Quality Control

Our 9H-Purin-6-Amine, 9-(2-Deoxy-2-Fluoro-β-D-Arabinofuranosyl)-2-Fluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.