Description

4-Thiothymidine is a chemically modified nucleoside analog of thymidine, where the oxygen atom at the 4-position of the pyrimidine ring is replaced by sulfur. This structural modification is critical for its role as a key intermediate and building block in the synthesis of novel oligonucleotides and therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antisense oligonucleotides, prodrugs, and other advanced nucleic acid-based therapies.

Application

• Antisense Oligonucleotide Synthesis: A vital phosphoramidite precursor for creating modified oligonucleotides used in gene silencing and therapeutic research.
• Prodrug Development: Serves as a core scaffold in the design and synthesis of nucleoside prodrugs targeting viral and cancer therapies.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate nucleotide metabolism and related pathways.
• Medicinal Chemistry: An essential intermediate for medicinal chemists exploring structure-activity relationships in novel nucleoside analogs.
• Diagnostic Probe Development: Employed in the creation of labeled probes for molecular diagnostics and imaging applications.

Basic Information

Product Name	4-Thiothymidine
CAS No.	134111-35-6
Molecular Formula	C10H14N2O4S
Molecular Weight	258.29 g/mol
Synonyms	4-Thio-2'-deoxythymidine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-thiothymine; 4-Thio-dT; 4-S-Thymidine; 2'-Deoxy-4-thiothymidine; 4-Thio-2'-deoxy-5-methyluridine; d4ST
EINECS	Contact for details

Quality Control

Our 4-Thiothymidine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and custom synthesis to meet specific pharmacopeial or customer-defined specifications is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.