Description

4'-Thiothymidine is a modified nucleoside analog where the oxygen atom in the furanose ring is replaced by sulfur, creating a unique 4'-thioribose structure. This molecular modification is critical for its role as a key intermediate and building block in the synthesis of novel antiviral and anticancer nucleoside analogs. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in developing next-generation therapeutic agents. The compound's distinct structure allows for the exploration of enhanced metabolic stability and binding affinity in drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of experimental antiviral and anticancer nucleoside drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and polymerase function.
• Antiviral Agent Development: A building block for creating analogs targeting viruses such as HIV, Hepatitis B, and other DNA viruses.
• Anticancer Drug Discovery: Incorporated into novel compounds designed to inhibit tumor cell proliferation by interfering with DNA synthesis.
• Proteomics & Genomics: Employed in the development of specialized probes and tools for studying gene expression and protein-nucleic acid interactions.
• Medicinal Chemistry: Utilized for structure-activity relationship (SAR) studies to optimize the pharmacokinetic properties of nucleoside-based therapeutics.

Basic Information

Product Name	4'-Thiothymidine
CAS No.	134111-33-4
Molecular Formula	C10H14N2O4S
Molecular Weight	258.29 g/mol
Synonyms	1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-sulfanylidene-1,3-oxathiolan-2-yl]-5-methylpyrimidine-2,4-dione; 2'-Deoxy-4'-thio-5-methyluridine; 4'-Thio-2'-deoxythymidine; d4ST; 4'-Thio-dT; 1-(4-Thio-β-D-erythro-pentofuranosyl)thymine
EINECS	Contact for details

Quality Control

Every batch of 4'-Thiothymidine is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available for review and provided with each shipment. We adhere to cGMP standards for the production of pharmaceutical intermediates to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.