Description

2'-Deoxy-4'-Thiouridine is a modified nucleoside analog where the oxygen atom at the 4' position of the ribose sugar is replaced by sulfur. This structural modification is of significant interest in the development of novel antiviral and anticancer therapeutics, as it can alter the metabolic stability and binding affinity of oligonucleotides. It serves as a critical building block for researchers in pharmaceutical development and molecular biology, particularly for the synthesis of modified DNA/RNA sequences and probes. This compound is essential for advanced life science research targeting nucleotide-based drug discovery and diagnostic applications.

Application

• Antiviral Drug Research: Key intermediate in the synthesis of nucleoside analogs targeting viral polymerases.
• Anticancer Agent Development: Used to create modified oligonucleotides that can disrupt cancer cell replication.
• Molecular Biology Probes: Acts as a building block for fluorescent or radioactive nucleotide probes used in hybridization and detection.
• Oligonucleotide Synthesis: Critical raw material for solid-phase synthesis of thio-modified DNA and RNA strands.
• Biochemical Research: Used in studies investigating DNA/RNA structure, function, and enzyme interactions.
• Diagnostic Kit Development: Component in the manufacture of specialized diagnostic assays and kits.

Basic Information

Product Name	2'-Deoxy-4'-Thiouridine
CAS No.	134111-32-3
Molecular Formula	C9H12N2O4S
Molecular Weight	244.27 g/mol
Synonyms	4'-Thio-2'-deoxyuridine; 1-[(2R,4S)-2-(Hydroxymethyl)-4-mercaptotetrahydrofuran-1-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; 2'-Deoxy-4'-thiouridine; 4'-Thio-dU; d4SU; 4'-Thio-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-4'-Thiouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines. Specifications are designed to meet the stringent requirements of pharmaceutical R&D and production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., argon or nitrogen) when possible and allowed to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.